| DATE | MATCH | RESULT |
|---|---|---|
| Aug 14, 2021 | Burnley – Brighton | 1-2 |
| Aug 21, 2021 | Brighton – Watford | 2-0 |
| Aug 24, 2021 | Cardiff – Brighton(CC) | 0-2 |
| Aug 28, 2021 | Brighton – Everton | 0-2 |
| Sep 11, 2021 | Brentford – Brighton | 0-1 |
| Sep 19, 2021 | Brighton – Leicester | 2-1 |
| Sep 22, 2021 | Brighton – Swansea(CC) | 2-0 |
| Sep 27, 2021 | C Palace – Brighton | 1-1 |
| Oct 2, 2021 | Brighton – Arsenal | 0-0 |
| Oct 16, 2021 | Norwich – Brighton | 0-0 |
| Oct 23, 2021 | Brighton – Man City | 1-4 |
| Oct 27, 2021 | Leicester – Brighton(CC) | 2-2 |
| Oct 30, 2021 | Liverpool – Brighton | 2-2 |
| Nov 6, 2021 | Brighton – Newcastle | 1-1 |
| Nov 20, 2021 | Aston Villa – Brighton | 2-0 |
| Nov 27, 2021 | Brighton – Leeds | 0-0 |
| Dec 1, 2021 | West Ham – Brighton | 1-1 |
| Dec 4, 2021 | Southampton – Brighton | 1-1 |
| Dec 15, 2021 | Brighton – Wolves | 0-1 |
| Dec 26, 2021 | Brighton – Brentford | 2-0 |
| Dec 29, 2021 | Chelsea – Brighton | 1-1 |
| Jan 2, 2022 | Everton – Brighton | 2-3 |
| Jan 8, 2022 | W Brom – Brighton(FA) | 1-2 |
| Jan 14, 2022 | Brighton – C Palace | 1-1 |
| Jan 18, 2022 | Brighton – Chelsea | 1-1 |
| Jan 23, 2022 | Leicester – Brighton | 1-1 |
| Feb 5, 2022 | Tottenham – Brighton(FA) | 3-1 |
| Feb 12, 2022 | Watford – Brighton | 0-2 |
| Feb 15, 2022 | Man Utd – Brighton | 2-0 |
| Feb 19, 2022 | Brighton – Burnley | 0-3 |
| Feb 26, 2022 | Brighton – Aston Villa | 0-2 |
| Mar 5, 2022 | Newcastle – Brighton | 2-1 |
| Mar 12, 2022 | Brighton – Liverpool | 0-2 |
| Mar 17, 2022 | Brighton – Tottenham | 0-2 |
| Mar 19, 2022 | Man City – Brighton | – |
| Apr 2, 2022 | Brighton – Norwich | – |
| Apr 9, 2022 | Arsenal – Brighton | – |
| Apr 16, 2022 | Tottenham – Brighton | – |
| Apr 23, 2022 | Brighton – Southampton | – |
| Apr 30, 2022 | Wolves – Brighton | – |
| May 7, 2022 | Brighton – Man Utd | – |
| May 15, 2022 | Leeds – Brighton | – |
| May 22, 2022 | Brighton – West Ham | – |
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